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In addition to the findings with ASMase knockout mice, which models the lysosomal storage disorder NiemannPick type A disease, inhibition of glucocerebrosidase in hepatocytes by conduritol -epoxide, a cellular model of Gaucher disease that exhibits lysosomal cholesterol accumulation sensitizes to APAP-induced cell death (Teratani et al., 2017)

Beuming T et al (2008): The binding sites for cocaine and dopamine in the dopamine transporter overlap

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Australia's regulatory alignment with FDA/EMA decisions means local approval timelines would likely lag global approval by 1224 months